An sabunta ta ƙarshe 27/12/2023 ta Dakunan shan magani - Kiwon Lafiyar Jama'a

Wannan shine yadda maganin kafeyin zai iya rage cutar Parkinson

Abin takaici, babu wani magani game da cutar ta Parkinson, amma yanzu masu bincike sun zo da wani sabon labari game da wani sabon bincike wanda suka gano cewa maganin kafeyin na iya hana gina wani sinadari wanda ke da alaƙa da haɓakar cutar. Karatun da suka gabata sun nuna cewa kofi tsakanin sauran abubuwa na iya rage lalata hanta. Wani dalili mai kyau don jin daɗin kyakkyawan kofi na sabon kofi a can.

Cutar Parkinson cuta ce mai saurin ci gaba wanda ke shafar tsarin jijiyoyi na tsakiya - musamman ma yanayin motsi. Bayyanar cututtukan Parkinson's na iya zama rawar jiki (musamman a hannu da yatsu), wahalar motsi da matsalolin yare. Ba a san ainihin abin da ya haifar da yanayin ba, amma sababbin karatu koyaushe suna nuna cewa furotin da ake kira alpha-synuclein na taka muhimmiyar rawa. Wannan furotin din zai iya nakasawa ya kuma samar da kumburin sunadaran da muke kira jikin Lewy. Wadannan jikin Lewy sun taru a wani sashi na musamman na kwakwalwa da ake kira substantia nigra - wani yanki ne na kwakwalwa wanda yake da hannu dumu-dumu a cikin motsi da samuwar kwayar halitta. Wannan yana haifar da raguwar samar da kwayar halitta, wanda ke haifar da matsalolin motsi na halayyar da aka gani a cikin kwayar cutar ta Parkinson.

Yanzu, masu bincike a Jami'ar Saskatchewan Kwalejin Magunguna sun haɓaka abubuwa biyu na tushen maganin kafeyin waɗanda suka yi imanin za su iya dakatar da alpha-synuclein daga taruwa a wannan yankin.

Kariya don samar da ƙwayoyin sel

Binciken da aka yi a baya ya kasance yana mai da hankali kan kare ƙwayoyin da ke samar da dopamine - amma kamar yadda masu binciken a cikin sabon binciken suka ce: "Yana taimakawa ne matuƙar akwai sel da suka rage don karewa." Don haka, suna da wata hanya dabam, wato a hana tara tarin jikin Lewy tun farko. Tare da binciken da ya gabata ya nuna cewa maganin kafeyin - wani abu mai mahimmanci wanda aka samo a cikin shayi, kofi da cola - yana da tasiri mai kariya a kan kwayoyin dopamine, masu bincike sun so su haɓaka da kuma gano takamaiman abubuwan da zasu iya hana irin wannan tarin furotin da aka ambata. Sun gano haka.

Kammalawa: Kayayyakin maganin kafeyin guda biyu na iya samar da tushen magani

Masu binciken sun gano wasu abubuwa guda biyu da ake kira C8-6-I da C8-6-N wadanda dukkansu sun baje kolin kadarorin da suke so - wato don daure da kuma hana furotin alpha-synuclein, wanda ke da alhakin tara jikin Lewy, daga nakasa. Don haka binciken ya kammala cewa binciken nasu zai iya ba da tushe ga sababbin hanyoyin jiyya waɗanda za su iya ragewa kuma watakila - yiwuwar - dakatar da lalacewar da ake gani a cikin cutar Parkinson. Bincike mai ban sha'awa kuma mai mahimmanci wanda zai iya ƙara ingancin rayuwa ga waɗanda abin ya shafa - da danginsu.

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nassoshi

"Novel dimer mahadi waɗanda ke ɗaure α-synuclein na iya ceton ci gaban sel a cikin ƙirar yisti mai wuce gona da iri α-synuclein. dabarun rigakafin cutar Parkinson, »Jeremy Lee et al., ACS Chemical Neuroscience, doi: 10.1021/acschemneuro.6b00209, wanda aka buga akan layi 27 Satumba 2016, m.