An sabunta ta ƙarshe 27/12/2023 ta Dakunan shan magani - Kiwon Lafiyar Jama'a

Sakamakon bincike na iya gano ciwon gajiya mai tsanani / ME

Ciwon gaji na yau da kullun shine rashin fahimta da rashin fahimta - ba tare da sanin magani ko sanadi ba. Yanzu sabon bincike ya samo hanyar da za a iya gano cutar ta hanyar gano wani sa hannu na sinadarai wanda ya bayyana yana cikin wadanda yanayin ya shafa. Wannan binciken zai iya haifar da saurin ganewar asali da hanyoyin magani masu tasiri a nan gaba.

Akwai masana kimiyya Jami'ar California San Diego School of Medicine wanda ke bayan ganowa. Ta hanyar jerin dabaru da nazari inda suka kimanta metabolites a cikin jini na jini - sun gano cewa waɗanda ke da ciwon gajiya na yau da kullun (wanda ake kira ME) suna da sa hannun sinadarai na gama gari da kuma tushen ilimin halitta. Don bayani, metabolites suna da alaƙa kai tsaye zuwa metabolism - kuma suna da alaƙa da matsakaicin matakan wannan. Masu bincike sun gano cewa wannan sa hannu ya kasance daidai da sauran jihohin hypometabolic (ƙananan metabolism) irin su diapause (hibernation), azumi da rashin barci - waɗanda galibi ana kiran su tare. Yanayin dindindin - yanayin da ke da alaƙa da dakatarwar ci gaba saboda matsanancin yanayin rayuwa (misali sanyi). Dauer ita ce kalmar Jamusanci don tsayin daka. Kuna da labari? Yi amfani da akwatin sharhi da ke ƙasa ko namu Facebook Page - ana iya samun dukkanin binciken binciken a mahadar da ke ƙasan labarin.

An bincika metabolites

Binciken yana da mahalarta 84; 45 tare da ganewar asali na Ciwon Gaji na Chronic (CFS) da mutane 39 masu lafiya a cikin ƙungiyar kulawa. Masu binciken sunyi nazarin bambance-bambancen metabolite 612 (kasuwanci da aka samo a cikin tsarin rayuwa) daga hanyoyin 63 daban-daban na biochemical a cikin jini na jini. Sakamakon ya nuna cewa waɗanda aka gano tare da CFS suna da rashin daidaituwa a cikin 20 na waɗannan hanyoyin biochemical. Kashi 80% na metabolites ɗin da aka auna kuma sun nuna raguwar aiki daidai da abin da ake gani a cikin rashin ƙarfi na metabolism ko ciwo na hypometabolic.

Tsarin sunadarai mai kama da "jihar Dauer"

Jagoran binciken, Naviaux, ya bayyana cewa, ko da yake akwai hanyoyi daban-daban don gano cutar gajiya mai tsanani - tare da abubuwa masu yawa masu yawa - mutum zai iya ganin siffar gama gari a cikin tsarin sinadarai. Kuma wannan shi kansa wani muhimmin ci gaba ne. Ya kara kwatanta wannan da "Dauer state" - martanin rayuwa da ake gani tsakanin kwari da sauran kwayoyin halitta. Wannan yanayin yana ba da damar kwayoyin halitta don rage karfin metabolism zuwa irin wannan matakan wanda zai tsira daga kalubale da yanayin da zai haifar da mutuwar kwayar halitta. Amma a cikin mutane, waɗanda aka gano suna da ciwo na gajiya mai tsanani, wannan zai haifar da bambance-bambancen, ciwo mai tsawo da rashin aiki.

Zai iya haifar da sabon magani na ciwo mai wahala / ME

Wannan tsarin sinadari yana samar da wata sabuwar hanya don tantancewa da gano ciwon gajiya mai tsanani - kuma ta haka zai iya haifar da saurin ganewar asali. Binciken ya nuna cewa kashi 25 cikin 75 na rikice-rikicen da aka ambata a baya ana buƙatar don tantance ganewar asali - amma cikakken kashi XNUMX% na sauran rikice-rikicen na musamman ne ga kowane mutum da abin ya shafa. Don haka na ƙarshe yana da alaƙa da gaskiyar cewa ciwon gajiya na yau da kullun yana canzawa kuma ya bambanta da mutum zuwa mutum. Tare da wannan ilimin, masu binciken suna fatan za su iya samar da ingantaccen magani ga yanayin - wani abu da yake matukar bukata.

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Hotuna: Wikimedia Commons 2.0, Creative Commons, Freemedicalphotos, Freestockphotos da kuma gudummawar mai karatu.

nassoshi:

Siffofin metabolism na ciwo na gajiya na yau da kullun, Robert K. Naviaux et al., PNAS, doi: 10.1073 / pnas.1607571113, wanda aka buga a yanar gizo Agusta 29, 2016.