Shin parabens zai iya haifar da cutar kansa ko cutar kansa? Hoto: Wikimedia

Shin parabens zai iya haifar da cutar kansa da ciwan ciki?

An yi iƙirarin cewa parabens, da aka samo a cikin samfuran kwalliya da yawa, na iya haifar da cutar kansa ta nono da cuta ta haɗarin ciki. Amma wannan gaskiya ne?

Methyl, ethyl, propyl, butyl, da benzyl parabens duk esters ne na p -hydroxybenzoic acid. Ana amfani da waɗannan azaman magungunan rigakafi a cikin kayan shafawa, kwayoyi, mat og sha. Saboda ƙarancin ƙarancin wadataccen kayan aikinsu da ƙarancin guba, ana amfani dasu a duk duniya.

Shin jiki zai iya kawar da kwayoyi?

Haka ne, bayan parabens su isa ga jini, ana iya hadasu cikin hanta tare da glycine, sulfate, ko glucoronate, sannan a fesa a cikin fitsari.

Koyaya, wasu parabens sune lipophilic, wanda ke haifar dasu shiga cikin fata kuma ana samun su cikin nama lokacin da aka gwada su. A zahiri, a cikin binciken, an gano tarawa tsakanin 20 ng / g rabo nama da 100 ng / g sashi rabo. (1)

Shin Parabens zai iya haifar da cutar kansa?

Parabens suna da rauni na aikin estrogenic kuma, a cikin nazarin micro (a cikin vitro), sun haifar da haɓakar ƙwayoyin ƙwayar nono na MCF-7. (2)

Akwai irin wannan sakamako wanda ya haifar da hasashe cewa ƙwayoyin cuta na iya haɓaka cutar kansa. Daga cikin wadansu abubuwa, an yi iƙirarin a cikin binciken cewa ƙararrakin ƙwayar nono sun fara zuwa a saman ɓangaren nono, a yankin da ake amfani da deodorant. (3) Wani binciken ya yi imanin cewa tasirin estrogenic ya yi ƙanƙantar da kai don kawo matsala ta gaske ga ƙwayoyin MCF-7 ko kuma duk wata haɗarin kiwon lafiya. (4)

Shin kwayoyi zasu iya haifar da matakan haɓakar isrogen da tsufa?

Wata hanyar, mafi rashin daidaituwa, hanyar da kwayoyi zasu iya tasiri aikin estrogenic shine ta hana ayyukan enzyme sulfotransferase a cikin cytosol (cytoplasm a waje da kwayoyin a cikin sel) akan sel.

Ta hanyar toshe enzymes na sulfotransferase, paraben na iya kai tsaye ya haifar da matakin estrogen. (5) Wasu sun yi imani da cewa parabens suna ɗaya daga cikin dalilan da suka sa 'yan mata su isa balaga a wani ƙarami, kamar yadda matakan estrogen suke ƙaruwa, don haka yana hanzarta aiwatarwa.

- Wasu nau'ikan parabens zasu iya toshe aikin mitochondrial

Wata hanyar, mafi rashin daidaituwa, hanyar da kwayoyi zasu iya tasiri aikin estrogenic shine ta hana ayyukan enzyme sulfotransferase a cikin cytosol (cytoplasm a waje da kwayoyin a cikin sel) akan sel.

Mitochondria sune cibiyar makamashin tantanin halitta. Nan ne inda aka samar da mafi yawan makamashin ATP (adenosine triphosphate). Methyl da propyl parabens sune abubuwa biyu waɗanda ke hana wannan nau'in ayyukan mitochondrial. (6, 7) Amma nazarin tsari na nazari ya kammala cewa hakane 'Ba zai yiwu ba a ce halittun parabens su kara barazanar kowane irin yanayin da za a tattauna tsakanin estrogen, gami da tasiri kan haihuwar namiji da cutar sankarar mama.'  (6) Yi haƙuri, amma kawai za mu fassara ƙarshen magana zuwa Yaren mutanen Norway.

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Thearshen…

Bincike bai iya nuna cewa parabens suna da haɗari kai tsaye ba… amma bisa ga sakamakon zamu iya yanke shawarar cewa ba shi da koshin lafiya kai tsaye.

Zai fi kyau a motsa jiki da amfani da samfuran paraben da ke dauke da hikima cikin hikima. Kamar yadda tare da komai. Smallauki ƙananan matakai don rage parabens, kamar amfani da hasken rana mara amfani.

Mai yiwuwa bincike na gaba zai ba mu amsoshi masu haske kan yadda parabens ke shafanmu, amma har zuwa yanzu, bincike ya nuna cewa ba su da haɗari sosai, amma ba wani abin da kuke so sosai ba.

Kafofin / Karatu:

1. Ji Ku¹, Lim Ku Y, Park Y, Choi K. Tasirin cin abinci mai cin ganyayyaki na kwanaki biyar akan matakan fitsari na maganin rigakafi da ƙwayoyin metabolites: nazarin matukin jirgi tare da mahalarta «Zaman Haikali». Yankin Res. 2010 Mayu; 110 (4): 375-82. doi: 10.1016 / j.envres.2010.02.008. Epub 2010 Mar 12.

2. Daga PD¹, Aljarrah A., Miller WR, Coldham NG, Sauron MJ, Paparoma GS. Ididdigar parabens a cikin ƙwayar nono ɗan adam. J Appl mai guba. 2004 Jan-Feb;24(1):5-13.

3. Xiaoyun Ya, Amber M. Bishop, John A. Reidy, Larry L. Needham, Da kuma Antonia M. Calafat. Parabens kamar Urinary Biomarkers na Bayyanawa a cikin Mutane. Yanayin Lafiya. 2006 Dec; 114 (12): 1843-1846.

4. Byford JR¹, Shaw LE, Daga MG, Paparoma GS, Sauron MJ, Daga PD. Ayyukan Estrogenic na parabens a cikin MCF7 ɗan adam kansar nono. J Steroid Biochem Mol Biol. 2002 Jan;80(1):49-60.

5. Daga PD¹, Harvey PW. Paraben esters: nazari game da binciken da aka yi kwanan nan game da cututtukan endocrine, sha, istrase da kuma bayyanar ɗan adam, da tattaunawa game da haɗarin lafiyar ɗan adam. J Appl mai guba. 2008 Jul;28(5):561-78. doi: 10.1002/jat.1358.

6.Zinare R¹, Gandi J, Volmer G. Binciken ayyukan endocrine na parabens da abubuwan da ke tattare da haɗarin da ke tattare da lafiyar ɗan adam. Crit Rev Toxicol. 2005 Jun;35(5):435-58.

7. Amintakayya JJ¹, Harville HM, Zhang Y, Ackermann C., Foreman RL. Parabens suna hana aikin mutum estrogen sulfotransferase aiki: hanyar haɗi mai yuwuwa ga paraben estrogenic effects. Toxicology. 2007 Apr 11; 232 (3): 248-56. Epub 2007 Jan 19.