Unyango olutsha lwe-Alzheimer libuyisela inkumbulo egcweleyo!

Isifo sika-Alzheimer

Unyango olutsha lwe-Alzheimer libuyisela inkumbulo egcweleyo!

Abaphandi base-Australia benze umnyhadala kunyango lwesifo i-Alzheimer's. Ngokusebenzisa uhlobo olululo lonyango, bakwazile ukubuyisela inkumbulo kunye nokusebenza kwengqondo. Kuyachulumancisa! Kwisifundo sezilwanyana esenziwe ngonyango olutsha, iipesenti ezingama-75 zeempuku ziphinde zafumana inkumbulo yazo.

 



Unyango lwe-plaque kwingqondo ene-ultrasound

Abaphandi bafumene indlela engonakalisiyo ye-ultrasound yendlela yokucoca ingqondo iapiyam ye-amyloid - into ene-neurotoxic ebandakanya i-aluminium silicate kunye neepeptides ze-amyloid. Eli cwecwe lakha malunga neeseli zemithambo-luvo kwingqondo kwaye ekugqibeleni linokukhokelela kwiimpawu zakudala zesifo se-Alzheimer's, njenge inkumbulo elahlekileyo, imemori umsebenzi og umsebenzi wokuqonda ongalunganga. Olu hlobo lwamacwecwe (ekwabizwa ngokuba yi-senile plaque) anokuqokelelana phakathi kwee-neurons kwaye agqibele njengamaqhuma Iimolekyuli ze-beta-amyloid -Iyiprotein ngokwayo eyenza i-plaque.

 

-Unyanga i-plaque, kodwa hayi ingqokelela ye-neurofibrillary

Unobangela wesibini wesifo sika-Alzheimer ingqokelela ye-neurofibrillary. Le yokugqibela ibangelwa ziiprotein zentambo ezingalunganga kwii-neurons ngaphakathi kwengqondo. Njenge-amyloid plaque, ezi ke ziyaqokelelana kwaye zenze ubunzima obungafakwanga. Oku kukhokelela kumonakalo kwizakhiwo ezibiziweyo microtubules kwaye zibangele ukuba zingalunganga, nto leyo ekhokelela ekunciphiseni ukuthuthwa kwezondlo ezifanelekileyo. Yicinge ngokungathi ubugqwetha kwaye utsala i-vacuum cleaner hose- kuya kuba nzima ngakumbi ukutsala izinto kunye neeplisi. Ngelishwa, akukho lunyango lwale nxalenye ye-Alzheimer's, kodwa kubonakala ngathi izinto ezinkulu sele ziza kwenzeka.

 

 

-Alukho unyango lwangaphambili lwe-Alzheimer's

Isifo esiqhelekileyo i-Alzheimer sichaphazela malunga nezigidi ezingama-50 zabantu emhlabeni. Ngaphambili, bekungekho nyango lulungileyo lwesi sifo, kodwa ngoku kubonakala ngathi izinto sele ziza kwenzeka. Njengoko kukhankanyiwe, isifo se-Alzheimer sibangelwa zizinto ezimbini:

  • I-Amyloid plaque
  • Iingqokelela ze-Neurofibrillary

Kwaye ngoku kubonakala ngathi umntu unokunyanga okwangaphambili ebantwini ngexesha elifutshane. Kuya kufuneka sikhumbule ukuba uphononongo olwenziweyo lwalukwimigundane, njengakwinqanaba laphambi kolunye unyango, kodwa kujongeka kuyathembisa.

 

Unyango lwe-Alzheimer-ngaphambili nangasemva kwe-ultrasound



-Ugxile kunyango lwe-ultrasound yonyango

Isifundo sipapashwe ngaphakathi Inzululwazi yokuguqulela isayensi Kwisifundo, abaphandi bachaza ukuba basebenzise njani uhlobo olukhethekileyo lwe-ultrasound ekuthiwa kugxilwe kunyango lwe-ultrasound- apho Amaza esandi angahlaseliyo adluliselwa kwizicubu ezonakalisiweyo zengqondo. Ngokushukuma okukhawulezayo okukhawulezayo, amaza esandi anokunceda ukuvula ngobunono isithintelo segazi-lobuchopho (umaleko okhusela ingqondo ngokuchasene neebhaktiriya kunye nokunye okunje) kunye nokukhuthaza ukusebenza kwingqondo. microglial. Ezokugqibela zezi, ukubeka ngokulula, iiseli zokususa inkunkuma- kwaye ngokwenza oku kusebenze, uphononongo lubonise ukuba iimolekyuli ezinobungozi ze-beta-amyloid zacocwa (jonga umzekeliso ongentla), kwaye njengoko sikhumbula, zezona zinto zibangela ezona mpawu zibi. kwisifo sika-Alzheimer.

 

Iipesenti ezingama-75 zabo baphathwa bephilile ngokupheleleyo

Uphononongo lubike ukuphuculwa okupheleleyo kwiipesenti ezingama-75 zeempuku abazisebenzisileyo kunyango- ngaphandle kweziphumo ebezingalindelekanga okanye ukonakala kwizihlunu zobuchopho ezikufutshane. Inkqubela phambili yalinganiswa ngeemvavanyo ezintathu: 1. ILabyrinth 2. Ukwamkelwa kwezinto ezintsha 3. Imemori yeendawo ekufuneka zithintelwe.

Rat kwi-maze

- Unyango ngaphandle kwamayeza

Unyango kunyango lwesifo i-Alzheimer ngaphandle kwamayeza, olunokuthi kwiimeko ezininzi lunokuba nenxalenye ephezulu yeziphumo ebezingalindelekanga, kumnandi kakhulu.

 

Izifundo zoLuntu ngo-2017

Kwiphepha lokupapashwa, u-Jürgen Götz, omnye wabaphandi, wathi bakwinkqubo yokuqalisa izifundo ezitsha zezilwanyana- kuquka neegusha. Kwaye banethemba lokuqala izifundo ebantwini sele zikwi-2017-2018 ukuba yonke into ihamba ngokwesicwangciso.



 

Funda: - Ijinja inokuwunciphisa umonakalo kwisifo esibuhlungu

Ijinja - I-painkiller yendalo

Funda: -Izinzuzo ezi-5 zempilo ngokwenza iplanga

Planken

Funda kwakhona: -Unyango olutsha lomhlaza lonyango lunokuthatha indawo yonyango ngemitha kunye nonyango ngamayeza!

Iiseli zihlasela iseli somhlaza

Ngaba uyazi ukuba: -Inyango ebandayo inokunika isiqabu seentlungu kumalungu aqaqanjelwa nezihlunu? Phakathi kwezinye izinto, I-Biofreeze (ungay-odola apha), equlathe ikakhulu iimveliso zendalo, yimveliso ethandwayo. Nxibelelana nathi namhlanje kwiphepha lethu le-Facebook, emva koko siya kulungisa enye coupon isaphulelo yeyakho.

Cold Treatment

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logo logoLandela i-Vondt.net kwi FACEBOOK

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Uncwadi olufanelekileyo:
«KwiPluto: Ngaphakathi kwiNgqondo ye-Alzheimer's« ngumboniso oqinileyo wokufumanisa ukuba unesifo i-Alzheimer kwaye uhlala nayo ngaphandle kokuncama. Incwadi ibhalwe ngumlobi-ntatheli, uGreg O'Brien, othe ngokweenkcazo ezigqwesileyo kunye namava obuqu akuthatha ukuba uwele ngokuthe chu ukuqhubela phambili kwisifo se-Alzheimer's.

umthombo:

I-Leinenga, G. kunye neGötz, J. Ukuskena i-ultrasound kususa i-amyloid-β kwaye kubuyise imemori kwimodeli yesifo semouse esine-Alzheimer's. SI-chience yokuGuqula  Ngomhla we-11 kaMatshi ngo-2015: Vol 7, ukukhutshwa 278.

Iifoto: I-Wikimedia Commons 2.0, iFreeStockPhotos, igalelo labafundi

Ukufudumeza iintlungu zomqolo - luthini uphando?

Ukufudumeza iintlungu zomqolo - luthini uphando?

 

Ubushushu budla ngokusetyenziswa ukunyibilikisa iintlungu zangasemva kunye nentlungu yomsipha ngokujikeleza umzimba, kodwa yintoni kanye kanye ethethwayo malunga nefuthe lobushushu kwintlungu yasemva? Sijika ngokuthe ngqo kuphando oluphambili kwicandelo, oko kukuthi, u-Cochrane meta-ukuhlaziywa. Kuhlalutyo lwe-meta, uphando olukhoyo ebaleni, kule meko, uqokelela ubushushu ngokuchasene neentlungu zangasemva, kwaye usixelele ukuba ngaba oku kuneziphumo zekliniki okanye akunjalo.

 

Ukushisa kunyango lwentlungu yangemva? -Ifoto yeWikimedia Commons

Ukufudumeza kunyango lwentlungu? -Iifoto ze-Wikimedia Commons

 

umphumela:

«Izilingo ezisithoba ezibandakanya abathathi-nxaxheba abali-1117 zibandakanyiwe. Kwizilingo ezimbini zabathathi-nxaxheba abangama-258 ngokudibanisa iintlungu ezibuhlungu kunye neentlungu ezisezantsi ezisezantsi, unyango lokugoqa ubushushu luyinciphise kakhulu intlungu emva kweentsuku ezintlanu (umahluko obonisa ubunzima (WMD) 1.06, 95% ithuba lokuzithemba (CI) 0.68 ukuya kwi-1.45, isikali Uluhlu lwe-0 ukuya kwi-5) xa kuthelekiswa ne-placebo yomlomo. Olunye uvavanyo lwabathathi-nxaxheba abangama-90 abaneentlungu ezibuhlungu ezisezantsi ezifumanise ukuba ingubo eshushu yanciphisa kakhulu iintlungu ezisezantsi emva nje kokufakwa kwesicelo (WMD -32.20, 95% CI -38.69 ukuya -25.71, umlinganiso we-0 ukuya kwi-100). Olunye uvavanyo lwabathathi-nxaxheba abangama-100 ngokudibanisa iintlungu ezibuhlungu ezisezantsi kunye nezibuhlungu ezisezantsi ezivavanye iziphumo ezongezelelekileyo zokongeza umthambo ekusongeleni ubushushu, kwaye bafumanisa ukuba kunciphisa iintlungu emva kweentsuku ezisixhenxe. Akukho bungqina baneleyo bokuvavanya iziphumo zokubandayo kwiintlungu ezisezantsi, kunye nobungqina obuphikisanayo bawo nawuphi na umahluko phakathi kobushushu nokubanda kweentlungu ezisezantsi. "

 

Izifundo ezili-9 nabathathi-nxaxheba abayi-1117 zabandakanywa kolu hlaziyo lweemeta. Unyango lobushushu lwanikezela isiqabu sobuhlungu emva kweentsuku ezintlanu ngokuthelekisa i-placebo. Olunye uphando kunye nabathathi-nxaxheba abangama-90 bafumanise ukuba ingubo yobushushu ibonelela ngoncedo olukhulu kwintlungu ephantsi kwangoko. Olunye uphononongo lubonise ukuba kubuhlungu obubuhlungu obukhulu kwaye buyibuyisela umva, ukudityaniswa kwonyango lokushisa kunye nokuzivocavoca kuvelise iziphumo zokunciphisa iintlungu ngaphezulu kweentsuku ezisi-7.

 

Isiphelo: 

«Isiseko sobungqina bokuxhasa isenzo esiqhelekileyo sobushushu obungaphezulu kunye nokubanda kweentlungu ezisezantsi ezinqunyelwe kwaye kukho imfuneko yezilingo ezilawulwa ngokungenamsebenzi kwikamva eliphezulu. Kukho ubungqina obumodareyitha kwinani elincinci lezilingo zokuba ubushushu busonga unyango lubonelela ukunciphisa okuncinci kwithuba elifutshane kwintlungu kunye nokukhubazeka kubemi ngokudibanisa iintlungu ezibuhlungu kunye neentlungu ezisezantsi, kwaye ukongezwa kokuzilolonga kuyaqhubeka kunciphisa iintlungu kunye nokuphucula ukusebenza. »

 

uphando (Nge-French et al, 2006) ithi izifundo ezingcono nezikhulu ziyafuneka ukuze ndikwazi ukuthetha into ngokuqinisekileyo malunga nonyango lobushushu kunyango lwentlungu lwasemva, kodwa kunjalo Iindlela ezincomekayo kwizifundo ezininzi. Umdibaniso wonyango olushushu kunye nokuzivocavoca kubonakala unegalelo elonyukayo.

 

Ke ukusebenzisa ubushushu ukunyanga iintlungu zangemva kunye nemisipha inokubonakala inayo isiphumo sokudambisa iintlungu.

 

-'Ubushushu bunokuba nefuthe elithozamisayo ngokuchasene nentlungu yasemva '- Ifoto Wikimedia

-Ubushushu bunokuba nefuthe lokuphucula iintlungu zomqolo '- Ifoto Wikimedia

 

Iimveliso eziKhuthazwayo:

Sincoma la mabhanti atshisa ubushushu alandelayo ngeentlungu ezisezantsi zomva:

Isigqubuthelo sobushushu ngomqolo ongezantsi- IPhoto Soothe

Isimbozo sobushushu se-lumbar spine-Ifoto Soothe

-Ibhanti eshushu (uGqirha Soothe) (funda ngakumbi okanye u-odole ngesi sikhonkwane)

 

Sicebisa oku kusongelwa kobushushu okulandelayo ngentlungu yentamo, amagxa kunye nomqolo ongaphezulu:

Isigqubuthelo sobushushu sentamo, amagxa kunye nomva wangasemva - Ifoto yeSunny

Isimbozo sobushushu sentamo, amagxa kunye nomqolo ongaphezulu- Ifoto Ilanga

Isembozo sobushushu kumqolo ongaphezulu, amagxa nentamo (iSunny Bay) (funda ngakumbi okanye u-odole ngesi sikhonkwane)

 

Khumbula ukuba umda wexabiso ukhuphukile uye kwi-NOK 350 ukusuka nge-01.01.2015. Siphinde sakhangela kwezi mveliso zilandelayo, kwaye zombini zithunyelwa eNorway ngexesha lokubhalwa.

 

Ukuba unayo nayiphi na imibuzo, kulungile ukuba uyithumele ngecandelo lezimvo ngezantsi okanye ngephepha lethu le-facebook. Siza kwenza konke okusemandleni ethu ukukunceda kwiiyure ezingama-24.

 

umthombo:

I-SD yaseFrance, iCameron M, i-Walker BF, iReggars yeJW, i-Esterman AJ. Ubushushu obugqithisileyo okanye ukubanda kwintlungu engemva ephantsi. Uvimba wedatha we-Cochrane woHlelo oluseMgangathweni 2006, Imeko 1. Ubugcisa. Hayi: CD004750. I-DoI: 10.1002 / 14651858.CD004750.pub2.

URL: http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD004750.pub2/abstract

 

amagama:
Ubushushu, iintlungu zangasemva, iintlungu zangasemva, iintlungu zemisipha, iintlungu, i-cochrane, isifundo

 

Funda:

- Inhlungu emqaleni?

- Ubuhlungu ngasemva?