Last updated 27/12/2023 by The pain clinics - Interdisciplinary Health

Stiff about the Morning? This is why!

A study published in the research journal FASEB has shown that there is a surprising reason why one is often stiff in the body in the morning - namely that the body's built-in "biological clock" produces and releases an anti-inflammatory protein called Cryptochrome which actively suppresses inflammation / inflammatory reactions at night.

This protein has proven anti-inflammatory effect in in vitro studies and provides new opportunities for the development of rheumatism drugs. This also shows how the body regulates its functions according to the rhythm of the day and how important a good night's sleep is for the recovery of muscles and joints - as well as the prevention of diseases. Do you have input? Use the comment field below or ours Facebook Page - the entire research study can be found at the link at the bottom of the article.

The findings in the research can also have a lot to say for the development of new drugs for rheumatic disorders - such as rheumatoid arthritis or Psoriasis arthritis.

The reason for morning stiffness

The morning stiffness is thus due to the fact that the body has fought unnecessary inflammation / inflammatory reactions throughout the night - which leaves some of the affected areas for cleansing through the blood circulation. When you move, your blood circulation increases and you take with you these "remnants" after the night's warfare and you gradually feel more obvious and flexible. Especially those with inflammatory arthritis are affected by this morning stiffness. To test this, researchers harvested tissue samples from joints, called fibroblast synoviocytes, which are known to be an important piece in inflammatory joint disease. These cells have a 24-hour circadian rhythm, and it was found that by interfering with this rhythm one could remove the function of cryptochrome the protein - which provided a basis for increased inflammation / inflammatory response. By reactivating the mentioned protein again - through drug treatment - it was seen that the inflammation was reduced again. Which emphasized the importance of this protein. PS - Of course, morning soreness is also related to muscular load and so-called «DOMS»Also.

May provide more effective drug treatment for inflammatory joint diseases

The study can lead to progress in relation to more effective drug treatment, and it can lead to changes in the time of day that this type of drug is administered - in order to have an optimal effect. The clinical ripple effects of this research may have much to say for those affected the consept of rheumatism.

Conclusion

Important and exciting research. The study otherwise emphasizes that man was created to sleep at night and that there is considerable "warfare" in the body against inflammation at this time. Something that may be worth noting if you work a lot of night shifts and feel that this really makes you stiff and numb - maybe it is related to increased inflammation in the body and joints. Previous studies have also shown that disturbance of the circadian rhythm (read: night shifts and the like) is directly linked to a higher incidence of cancer and stroke. (Editor's note: Study by Papagiannakopoulos et al, 2016). Otherwise, it is known from the past that exercise and a good diet also help to combat joint problems - so do not forget the daily trip or training session. If you want to read the whole study, you will find a link at the bottom of the article.

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References:

Article: The circadian clock regulates inflammatory arthritis, Laura E. Hand, Thomas W. Hopwood, Suzanna H. Dickson, Amy L. Walker, Andrew SI Loudon, David W. Ray, David A. Bechtold, and Julie E. Gibbs, PHASE BJ, doi: 10.1096 / fj.201600353R, published online August 3, 2016.