- New Treatment Dissolves Blood Clot 4000x More Effectively

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Last updated 18/03/2022 by The pain clinics - Interdisciplinary Health

Autoimmune diseases

- New Treatment Dissolves Blood Clot 4000x More Effectively

A new study in the scientific journal Scientific Reports has shown amazing results regarding a brand new treatment for blood clots. It showed that the new form of treatment - a treatment given via magnetic nanoparticles - is as much as 4000 times more effective than the traditional drugs that are used now. It was also noted that they are considerably more gentle than today's treatment. You can read the entire research study via the link at the bottom of the article.


Blood clots, which lead to both heart attack and stroke, are a leading cause of death worldwide. In such acute cases, rapid emergency treatment is necessary - the faster, the better. The purpose of this treatment is to dissolve the blood clot that blocks the blood supply to the area, so that the blood can flow freely again in the affected artery. The problem with current treatment is that they often affect healthy, healthy blood vessels close to the vein you want to treat - with the new treatment, with magnetic nanoparticles, you can be much more accurate and thus avoid unwanted damage to these structures. Is this the future in acute blood clot treatment?

 

AS 2

- The study can show the way to future treatment

The researchers hope that this can be the way to a more effective treatment without the side effects that are often experienced with current treatment. The reason for avoiding adverse side effects is that this drug, based on magnetic nanoparticle enzymes, can be injected and then directed against the blood clot.

 

- Today's current treatment works in only 15% of cases

The drugs currently used are not effective. The study estimates that in well-developed countries, such as Norway, only 15% of treatment is still effective. There are several reasons why it lacks efficacy and has a number of side effects:

  • The immune system: Immediately after the drug is injected, the body's immune system will attack it. The attack causes the drug to weaken significantly and the longer it takes before it reaches the blood clot, the more reduced it becomes in strength.
  • Large doses: To overcome the problem of the immune system weakening the drugs, very large doses are added - this in the hope that some of the drugs will reach the blood clot before they become ineffective. The researchers in the study say it's like "Using a sledgehammer to crush a nut" - and this also explains why healthy blood vessels throughout the body can be negatively affected by the large supply of medication.



- The new form of treatment solves these problems

With the new form of treatment, which is specific, both of these problems can be bypassed. They have solved the problems as follows:

  • Protection: They use a material, a composite of magnetite and urokinase, to transport the nanoparticle enzymes to the clot. This acts as a shell and prevents the body's immune system from attacking the drug and weakening it until it reaches the blood clot.
  • Specific smaller doses = minor side effects: Because you can transport and control the protected drug enzymes directly to the area, via external magnets, you no longer need to add huge doses in the hope that some of it can have an effect. This will also avoid the side effects that can occur at high doses.

 

- 4000 times more efficient

Researcher Andrey Drosdov further stated that "This new drug can dissolve blood clots 4000 times more effectively than unprotected enzymes". He also stated that all the materials used in the new drug have been previously approved for intravenous injection. The researchers are now conducting clinical studies to further develop the form of treatment and ensure that it is safe in human treatment.

Doctor talking to patient

- Can prevent blood clots?

The researchers will also study further whether the drug can have a preventive role when it comes to treating blood clots, as it can circulate in the blood and gently cleanse the blood vessels before it breaks down naturally by the liver eventually.

 

Conclusion:

Very, very exciting research! This is absolutely amazing! We hope that you help us to share this article on social media, on websites and the like - so that research, also in Norway, can focus on such an important form of treatment of a condition that affects so many.

 

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Photos: Wikimedia Commons 2.0, Creative Commons, Freestockphotos and submitted reader contributions.

 

References and research sources:

Andrey S. Drozdov, Vasiliy V. Vinogradov, Ivan P. Dudanov, Vladimir V. Vinogradov. Leach-proof magnetic thrombolytic nanoparticles and coatings of enhanced activity. Scientific Reports, 2016; 6: 28119 DOI: 10.1038 / srep28119

Vinogradov VV, Vinogradov AV, Sobolev VE, Dudanov IP & Vinogradov VV Plasminogen activator entrapped within injectable alumina: a novel approach to thrombolysis treatmentJ. Sol-Gel Sci. Technol. 73, 501-505 (2015).

Chapurina Y. et al. . Synthesis of Thrombolytic Sol-Gel Coatings: Toward Drug-Entrapped Vascular GraftsJ.Med. Chem. 58, 6313-6317 (2015). [PubMed]

Drozdov A., Ivanovski V., Avnir D. & Vinogradov V. A universal magnetic ferrofluid: Nanomagnetite stable hydrosol with no added dispersants and at neutral pHJ. Colloid Interface Sci.468, 307-312 (2016). [PubMed]

Drozdov A., Shapovalova O., Ivanovski V., Avnir D. & Vinogradov VV Entrapment of enzymes within sol-gel-derived magnetiteChem. Mater. 28, 2248-2253 (2016).

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1 answer
  1. Anita says:

    When you see how Norwegian politicians neglect cancer patients by not giving them the necessary medicine, this kind of treatment will not be available in our lifetime either. In this country, the money is the most important.

    SVAR

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